Research areas

Calliditas is dedicated to identifying, developing and commercializing novel treatments in orphan indications, with an initial focus on renal diseases with significant unmet medical needs.

The gut – an unexpected culprit in IgAN

IgA nephropathy

IgAN – also known as Berger’s disease – is the most common form of glomerulonephritis, a chronic inflammatory condition of the kidney. Currently, there are no approved treatments for IgAN.1

Nefecon

Nefecon is a targeted and sustained-release formulation of budesonide designed to deliver the drug to the ileum where the Peyer’s patches are concentrated and where IgAN is thought to originate.1,2

Scientific Steering Commitee

Nefecon is being studied in patients with IgAN at risk of developing end-stage renal disease, with help from some of the most prominent IgAN specialists in the world serving as external advisors and members of the company’s Scientific Study Steering Committee.3

References

  1. Barratt J, Rovin BH, Cattran D et al. Why target the gut to treat IgA nephropathy? KI Reports 2020;5:1620–1624.
  2. Fellstrom BC, Barratt J, Cook H et al. Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): a double-blind, randomised, placebo-controlled phase 2b trial. Lancet 2017;389:2117–2127.
  3. Calliditas Therapeutics AB. Efficacy and safety of Nefecon in patients with primary IgA (immunoglobulin A) nephropathy (Nefigard). 2019. Available at: https://clinicaltrials.gov/ct2/show/NCT03643965 [accessed 28 April 2020].